{"id":35620,"date":"2024-02-16T09:50:00","date_gmt":"2024-02-16T09:50:00","guid":{"rendered":"https:\/\/algarve7.pt\/?p=35620"},"modified":"2024-02-15T14:52:05","modified_gmt":"2024-02-15T14:52:05","slug":"investigador-da-ualg-envolvido-na-descoberta-de-travao-fisiologico-que-impede-a-formacao-de-memorias-traumaticas","status":"publish","type":"post","link":"https:\/\/algarve7.pt\/index.php\/2024\/02\/investigador-da-ualg-envolvido-na-descoberta-de-travao-fisiologico-que-impede-a-formacao-de-memorias-traumaticas\/saude\/09\/50\/","title":{"rendered":"Investigador da UAlg envolvido na descoberta de \u201ctrav\u00e3o\u201d fisiol\u00f3gico que impede a forma\u00e7\u00e3o de mem\u00f3rias traum\u00e1ticas"},"content":{"rendered":"\n

David Brito, investigador do Algarve Biomedical Center Research Institute da Universidade do Algarve, acaba de publicar um artigo na revista cient\u00edfica Molecular Psychiatry, em colabora\u00e7\u00e3o com investigadores do Central Institute of Mental Health (Alemanha), da Universidade de Heidelberg (Alemanha) e da Vrije Universiteit Amsterdam (Holanda) que revela um novo mecanismo biol\u00f3gico que pode desempenhar um papel na regula\u00e7\u00e3o da resili\u00eancia a eventos adversos da vida.<\/strong><\/p>\n\n\n\n

Atrav\u00e9s de experi\u00eancias realizadas em murganhos, o grupo de investigadores, composto por David Brito e Janina Kupke e liderado por Ana MM Oliveira (Central Institute of Mental Health \u2013 Universidade de Mannheim – Alemanha), descobriu que a forma\u00e7\u00e3o de mem\u00f3rias traum\u00e1ticas de alto impacto envolve um processo molecular \u00fanico que n\u00e3o se encontra presente na forma\u00e7\u00e3o e consolida\u00e7\u00e3o de mem\u00f3rias de medo de menor impacto. <\/p>\n\n\n\n

De acordo com os investigadores, enquanto as mem\u00f3rias de medo s\u00e3o essenciais para a sobreviv\u00eancia do organismo, pois desencadeiam respostas adequadas que permitem a adapta\u00e7\u00e3o ao ambiente, a exposi\u00e7\u00e3o a experi\u00eancias traum\u00e1ticas, por sua vez, pode conduzir \u00e0 forma\u00e7\u00e3o de mem\u00f3rias traum\u00e1ticas fortes que conduzem ao desenvolvimento de patologias psiqui\u00e1tricas graves, como a perturba\u00e7\u00e3o de stress p\u00f3s-traum\u00e1tico.<\/p>\n\n\n\n

Como explicam \u201cessas mem\u00f3rias fortes s\u00e3o caracterizadas por respostas desproporcionais de medo em rela\u00e7\u00e3o a situa\u00e7\u00f5es n\u00e3o relacionadas ao evento traum\u00e1tico inicial e pela incapacidade de extinguir esses medos\u201d.<\/p>\n\n\n\n

Os investigadores debru\u00e7aram-se sobre os processos biol\u00f3gicos subjacentes que impedem a forma\u00e7\u00e3o de mem\u00f3rias traum\u00e1ticas.<\/p>\n\n\n\n

Para este efeito, e usando os murganhos como modelo, os neurocientistas descobriram que modelando o fator de transcri\u00e7\u00e3o Npas4, um gene envolvido na regula\u00e7\u00e3o do desenvolvimento e fun\u00e7\u00e3o neuronal, era poss\u00edvel produzir uma resposta por forma a que as mem\u00f3rias traum\u00e1ticas ficassem mais fracas, diminuindo, assim as respostas e os eventos de medo.<\/p>\n\n\n\n

Os investigadores mostraram ainda que a exposi\u00e7\u00e3o a uma experi\u00eancia aversiva conduz a dois per\u00edodos elevados do fator de transcri\u00e7\u00e3o Npas4, sendo que o segundo per\u00edodo, onde os investigadores atuaram artificialmente modelando a prote\u00edna, revelou ter uma import\u00e2ncia decisiva uma vez que pode atuar como um \u201ctrav\u00e3o\u201d que impede a forma\u00e7\u00e3o de mem\u00f3rias traum\u00e1ticas muito intensas.<\/p>\n\n\n\n

A investiga\u00e7\u00e3o mostra, assim, o papel fundamental desta prote\u00edna na regula\u00e7\u00e3o dos contactos e comunica\u00e7\u00e3o entre neur\u00f3nios, demonstrando que quando \u00e9 tardiamente \u201cativada\u201d, leva \u00e0 presen\u00e7a do neurotransmissor respons\u00e1vel por reduzir a atividade neuronal, possivelmente regulando a intensidade de mem\u00f3rias traum\u00e1ticas. <\/p>\n\n\n\n

Para os respons\u00e1veis pela investiga\u00e7\u00e3o este estudo reveste-se de especial import\u00e2ncia uma vez que \u201capresenta o Npas4 como um alvo molecular que pode ser usado para o desenvolvimento de novas terapias\u201d.<\/p>\n\n\n\n

De acordo com a equipa de investiga\u00e7\u00e3o, em estudos futuros, ser\u00e1 importante compreender por que raz\u00e3o este mecanismo de prote\u00e7\u00e3o intr\u00ednseco \u00e9 por vezes contornado, formando-se mem\u00f3rias traum\u00e1ticas patol\u00f3gicas. <\/p>\n\n\n\n

Esta descoberta revelou uma estrat\u00e9gia biol\u00f3gica at\u00e9 ent\u00e3o desconhecida que parece impedir que experi\u00eancias de medo altamente aversivas originem a mem\u00f3rias fortes que poderiam estar subjacentes ao desenvolvimento de condi\u00e7\u00f5es psiqui\u00e1tricas.<\/p>\n","protected":false},"excerpt":{"rendered":"

David Brito, investigador do Algarve Biomedical Center Research Institute da Universidade do Algarve, acaba de publicar um artigo na 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