{"id":19318,"date":"2022-06-08T11:35:36","date_gmt":"2022-06-08T10:35:36","guid":{"rendered":"https:\/\/algarve7.pt\/?p=19318"},"modified":"2022-06-08T11:35:37","modified_gmt":"2022-06-08T10:35:37","slug":"investigadores-da-ualg-lideram-estudo-que-revela-novo-biomarcador-clinico-do-cancro-da-mama","status":"publish","type":"post","link":"https:\/\/algarve7.pt\/index.php\/2022\/06\/investigadores-da-ualg-lideram-estudo-que-revela-novo-biomarcador-clinico-do-cancro-da-mama\/saude\/11\/35\/","title":{"rendered":"Investigadores da UAlg lideram estudo que revela novo biomarcador cl\u00ednico do cancro da mama"},"content":{"rendered":"\n

Estamos na era de “personalizar” os tratamentos do cancro, o que s\u00f3 poder\u00e1 acontecer se compreendermos melhor o modo como os tumores se desenvolvem e comportam durante a terap\u00eautica. Seguindo esta linha de racioc\u00ednio, um grupo de investigadores, liderado por Ana Teresa Maia, docente da Universidade do Algarve (UAlg) e investigadora do Centro de Investiga\u00e7\u00e3o em Tecnologias e Servi\u00e7os de Sa\u00fade (CINTESIS), acaba de publicar um artigo na revista\u00a0npj Breast Cancer<\/em>\u00a0que identifica um novo biomarcador para progn\u00f3stico em pacientes com cancro da mama.\u00a0<\/strong><\/p>\n\n\n\n

Este biomarcador est\u00e1 associado \u00e0s muta\u00e7\u00f5es mais comuns do cancro da mama e poder\u00e1 ajudar a identificar o tratamento mais adequado para cada paciente.<\/p>\n\n\n\n

A investigadora Ana Teresa Maia refere: \u201cNeste trabalho olh\u00e1mos para o gene PIK3CA, que \u00e9 o mais frequentemente mutado em tumores da mama, e tent\u00e1mos perceber a sua import\u00e2ncia cl\u00ednica, que at\u00e9 agora era bastante elusiva\u201d. Os investigadores descobriram que quando avaliam estas muta\u00e7\u00f5es de modo diferente do que \u00e9 feito atualmente elas t\u00eam um car\u00e1cter cl\u00ednico importante, sendo indicadoras do progn\u00f3stico de cada paciente. \u201c\u00c9 como se olh\u00e1ssemos a mesma coisa, mas com \u00f3culos diferentes\u201d, refere a investigadora. Ana Teresa Maia explica ainda: \u201cDas v\u00e1rias mol\u00e9culas que existem numa c\u00e9lula, o ADN cont\u00e9m a informa\u00e7\u00e3o b\u00e1sica acerca do funcionamento celular, incluindo as muta\u00e7\u00f5es respons\u00e1veis pelos tumores. Mas o ARN revela a express\u00e3o dessa informa\u00e7\u00e3o, ou seja, representa a forma como a informa\u00e7\u00e3o \u00e9 lida. Foi ao olhar para o ARN de tumores de diversos centros cl\u00ednicos que identific\u00e1mos uma rela\u00e7\u00e3o entre a express\u00e3o das muta\u00e7\u00f5es e a probabilidade de sobreviv\u00eancia destas pacientes, as caracter\u00edsticas cl\u00ednicas e moleculares dos tumores, assim como os mecanismos que pensamos estar subjacentes a estas associa\u00e7\u00f5es.\u201d <\/p>\n\n\n\n

Este trabalho contou com a colabora\u00e7\u00e3o de parceiros da University of Cambridge e do Netherlands Cancer Institute, entre outros.<\/p>\n\n\n\n

Questionada sobre o impacto que esta descoberta poder\u00e1 vir a ter na comunidade ou na vida das pessoas, Ana Teresa Maia explica que \u201cdesde o ano passado que foi aprovado o uso de um f\u00e1rmaco espec\u00edfico para tratamento de tumores com estas muta\u00e7\u00f5es. N\u00f3s acreditamos que estudos como o nosso v\u00eam ajudar a identificar com alta precis\u00e3o as pacientes que podem beneficiar deste tratamento inovador\u201d. <\/p>\n\n\n\n

Os resultados alcan\u00e7ados s\u00e3o cruciais para pacientes e m\u00e9dicos. \u201cAs pacientes porque veem melhorias na compreens\u00e3o da doen\u00e7a e na sua gest\u00e3o cl\u00ednica, o que leva a um aumento da qualidade de vida e das chances de sobreviv\u00eancia. Os m\u00e9dicos, porque v\u00e3o ter mais uma pe\u00e7a do puzzle nas m\u00e3os, que lhes vai aumentar a confian\u00e7a nas suas decis\u00f5es cl\u00ednicas\u201d, conclui a investigadora.<\/p>\n\n\n\n

Este trabalho j\u00e1 deu origem a um pedido de patente para o desenvolvimento de testes para integra\u00e7\u00e3o na pr\u00e1tica cl\u00ednica e foi tamb\u00e9m premiado pela Ag\u00eancia Nacional de Inova\u00e7\u00e3o (ANI), atrav\u00e9s do concurso Born from Knowledge (BfK) Ideas, que pretende promover uma cultura de valoriza\u00e7\u00e3o do conhecimento cient\u00edfico e tecnol\u00f3gico em Portugal. Atualmente, foi criada uma spin-off instalada na UALG TEC START, incubadora da UAlg, para licenciamento e desenvolvimento da tecnologia.<\/p>\n","protected":false},"excerpt":{"rendered":"

Estamos na era de “personalizar” os tratamentos do cancro, o que s\u00f3 poder\u00e1 acontecer se compreendermos melhor o modo como<\/p>\n","protected":false},"author":1,"featured_media":19319,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"colormag_page_container_layout":"default_layout","colormag_page_sidebar_layout":"default_layout","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[59],"tags":[36,58,182],"class_list":["post-19318","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-saude","tag-algarve","tag-saude","tag-ualg"],"yoast_head":"\nInvestigadores da UAlg lideram estudo que revela novo biomarcador cl\u00ednico do cancro da mama - 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