{"id":14775,"date":"2022-01-20T16:05:27","date_gmt":"2022-01-20T16:05:27","guid":{"rendered":"https:\/\/algarve7.pt\/?p=14775"},"modified":"2022-01-20T16:05:32","modified_gmt":"2022-01-20T16:05:32","slug":"identificados-os-primeiros-pacientes-com-nova-doenca-rara-causada-por-erros-na-divisao-celular","status":"publish","type":"post","link":"https:\/\/algarve7.pt\/index.php\/2022\/01\/identificados-os-primeiros-pacientes-com-nova-doenca-rara-causada-por-erros-na-divisao-celular\/saude\/16\/05\/","title":{"rendered":"Identificados os primeiros pacientes com nova doen\u00e7a rara causada por erros na divis\u00e3o celular"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Um novo estudo publicado na Science Advances descreve os dois primeiros pacientes com muta\u00e7\u00f5es em ambas as c\u00f3pias de&nbsp;<em>BUB1<\/em>, um gene crucial para a divis\u00e3o celular. Contrariamente ao que se pensava, estas muta\u00e7\u00f5es s\u00e3o compat\u00edveis com a vida, apesar de estarem associadas a problemas do desenvolvimento. A identifica\u00e7\u00e3o e a carateriza\u00e7\u00e3o cl\u00ednica e molecular destas muta\u00e7\u00f5es podem vir a melhorar o diagn\u00f3stico deste dist\u00farbio raro do neurodesenvolvimento e a compreens\u00e3o de s\u00edndromes com carater\u00edsticas semelhantes.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><br>Quando as c\u00e9lulas se dividem, atrav\u00e9s de um processo designado de mitose, \u00e9 essencial que a informa\u00e7\u00e3o gen\u00e9tica seja equitativamente distribu\u00edda pelas novas c\u00e9lulas. \u00c9 neste momento que poder\u00e3o surgir erros na divis\u00e3o, que podem levar a danos nas mol\u00e9culas de ADN que cont\u00eam a informa\u00e7\u00e3o gen\u00e9tica (cromossomas), ou a altera\u00e7\u00f5es do seu n\u00famero. Estes erros est\u00e3o associados a diversas patologias humanas.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Uma das prote\u00ednas respons\u00e1veis pela monitoriza\u00e7\u00e3o de problemas na divis\u00e3o celular \u00e9 codificada pelo gene&nbsp;<em>BUB1<\/em>. Defeitos no gene&nbsp;<em>BUB1<\/em>&nbsp;t\u00eam sido associados a cancro, mas o papel deste gene no desenvolvimento humano \u00e9 ainda pouco conhecido. A express\u00e3o reduzida de&nbsp;<em>BUB1<\/em>&nbsp;est\u00e1 associada a abortos espont\u00e2neos e, dada a sua import\u00e2ncia para uma divis\u00e3o celular correta, at\u00e9 agora pensava-se que muta\u00e7\u00f5es desfavor\u00e1veis neste gene eram incompat\u00edveis com a vida.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Um esfor\u00e7o colaborativo entre m\u00e9dicos e cientistas de Portugal, da \u00c1ustria, e dos Pa\u00edses Baixos levou \u00e0 identifica\u00e7\u00e3o dos primeiros pacientes com muta\u00e7\u00f5es bial\u00e9licas (em ambas as c\u00f3pias) no gene&nbsp;<em>BUB1<\/em>. \u201cFoi surpreendente encontrar pacientes com muta\u00e7\u00f5es num gene t\u00e3o importante\u201d, explica Raquel Oliveira, l\u00edder da equipa do Instituto Gulbenkian de Ci\u00eancia (IGC) que conduziu o estudo. Mesmo assim, os pacientes apresentam microcefalia (uma malforma\u00e7\u00e3o cong\u00e9nita em que o c\u00e9rebro \u00e9 anormalmente pequeno), atrasos cognitivos e diversas carater\u00edsticas espec\u00edficas.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Investigadores do IGC exploraram ainda de que forma as variantes patol\u00f3gicas deste gene afetavam a divis\u00e3o celular. \u201cMostr\u00e1mos como \u00e9 que cada muta\u00e7\u00e3o afetava os n\u00edveis e a fun\u00e7\u00e3o da prote\u00edna, assim como o impacto destas nas diferentes vias que controlam a mitose\u201d, detalha Sara Carvalhal, primeira autora do estudo e antiga investigadora do IGC. Apesar de ambos os pacientes apresentarem c\u00e9lulas com altera\u00e7\u00f5es num\u00e9ricas ou estruturais nos cromossomas, os mecanismos moleculares subjacentes a esses erros na divis\u00e3o celular diferem entre eles. De acordo com Job de Lange, investigador do Cancer Center Amsterdam e cocoordenador do trabalho, \u201cestes resultados permitem dissecar os diferentes pap\u00e9is de&nbsp;<em>BUB1<\/em>&nbsp;num contexto cl\u00ednico\u201d.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><br>Para al\u00e9m de elucidar acerca das fun\u00e7\u00f5es do gene&nbsp;<em>BUB1<\/em>, este estudo esclarece tamb\u00e9m \u201co impacto que os erros mit\u00f3ticos t\u00eam no desenvolvimento do corpo humano\u201d. Os resultados obtidos apoiam a ideia de que o c\u00e9rebro em desenvolvimento \u00e9 particularmente suscet\u00edvel a erros na mitose. Os autores sugerem que os erros mit\u00f3ticos descritos podem causar a morte de c\u00e9lulas importantes para o desenvolvimento cerebral, sendo respons\u00e1veis pelas manifesta\u00e7\u00f5es cl\u00ednicas deste novo dist\u00farbio heredit\u00e1rio do neurodesenvolvimento, como a microcefalia e o atraso cognitivo. Sara Carvalhal ir\u00e1 agora dedicar-se a esta linha de investiga\u00e7\u00e3o e estudar o efeito dos erros na divis\u00e3o celular nas doen\u00e7as raras no seu pr\u00f3prio laborat\u00f3rio no Algarve Biomedical Center.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A maioria das doen\u00e7as raras continua muito pouco estudada e \u00e9 dif\u00edcil de diagnosticar. No futuro, estes resultados poder\u00e3o ajudar a prevenir um diagn\u00f3stico errado ou a aus\u00eancia de um diagn\u00f3stico em indiv\u00edduos que tenham muta\u00e7\u00f5es prejudiciais no gene&nbsp;<em>BUB1<\/em>, com consequ\u00eancias diretas no seu tratamento, progn\u00f3stico e acompanhamento. Em crian\u00e7as com microcefalia prim\u00e1ria ou com m\u00faltiplas malforma\u00e7\u00f5es cong\u00e9nitas, muta\u00e7\u00f5es germinativas bial\u00e9licas em&nbsp;<em>BUB1<\/em>devem ser consideradas como causais de forma mais frequente do que acontece atualmente\u201d, enfatiza Ingrid Bader, MD e coautora do estudo, da Paracelsus Medical University, Salzburgo, \u00c1ustria e atualmente no Institute for Medical Genetics and Applied Genomics em Tuebingen, na Alemanha.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Este estudo contribui tamb\u00e9m para a compreens\u00e3o de doen\u00e7as raras com carater\u00edsticas cl\u00ednicas e moleculares semelhantes \u00e0s dos pacientes descritos, como a aneuploidia variegada em mosaico (MVA), as coesinopatias e a microcefalia prim\u00e1ria (MCPH).&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">O estudo foi desenvolvido pelo Instituto Gulbenkian de Ci\u00eancia em colabora\u00e7\u00e3o com o Algarve Biomedical Center Research Institute, Portugal; a Unit of Clinical Genetics da Paracelsus Medical University, o Department of Pediatrics da University Hospital Salzburg, o Institute of Human Genetics do Diagnostic and Research Center for Molecular BioMedicine, \u00c1ustria; o Cancer Center Amsterdam, o Department of Clinical Genetics dos Amsterdam University Medical Centers, e Northwest Clinics, Pa\u00edses Baixos.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">O financiamento foi atribu\u00eddo pela Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia (FCT), pela Dutch Cancer Society, pelo European Molecular Biology Laboratory (EMBL), e pelo Austrian Science Fund.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Artigo Cient\u00edfico:<\/strong>&nbsp;Sara Carvalhal, Ingrid Bader, Martin A. Rooimans, Anneke B. Oostra, Jesper A. Balk, Ren\u00e9 G. Feichtinger, Christine Beichler, Michael R. Speicher, Johanna M. van Hagen, Quinten Waisfisz, Mieke van Haelst, Martijn Bruijn, Alexandra Tavares, Johannes A. Mayr, Rob M. F. Wolthuis, Raquel A. Oliveira, Job de Lange (2022).&nbsp;<strong>Biallelic BUB1 mutations cause microcephaly, developmental delay, and variable effects on cohesion and chromosome segregation.&nbsp;<\/strong>Science Advances.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>DOI:\u00a0<\/strong>doi\/10.1126\/sciadv.abk0114<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Defective chromosome separation in a cell derived from a patient with biallelic mutations in the BUB1 gene.\u00a0Mitotic chromosomes, magenta; centromeres, green; spindle, blue \u00a9 Sara Carvalhal, 2022<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Um novo estudo publicado na Science Advances descreve os dois primeiros pacientes com muta\u00e7\u00f5es em ambas as c\u00f3pias de&nbsp;BUB1, um<\/p>\n","protected":false},"author":1,"featured_media":14776,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"colormag_page_container_layout":"default_layout","colormag_page_sidebar_layout":"default_layout","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[59],"tags":[132,58],"class_list":["post-14775","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-saude","tag-abc","tag-saude"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Identificados os primeiros pacientes com nova doen\u00e7a rara causada por erros na divis\u00e3o celular - Algarve 7<\/title>\n<meta name=\"description\" content=\"Identificados os primeiros pacientes com nova doen\u00e7a rara causada por erros na divis\u00e3o celular Sa\u00fade\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/algarve7.pt\/index.php\/2022\/01\/identificados-os-primeiros-pacientes-com-nova-doenca-rara-causada-por-erros-na-divisao-celular\/saude\/16\/05\/\" \/>\n<meta property=\"og:locale\" content=\"pt_PT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Identificados os primeiros pacientes com nova doen\u00e7a rara causada por erros na divis\u00e3o celular - Algarve 7\" \/>\n<meta property=\"og:description\" content=\"Identificados os primeiros pacientes com nova doen\u00e7a rara causada por erros na divis\u00e3o celular Sa\u00fade\" \/>\n<meta property=\"og:url\" content=\"https:\/\/algarve7.pt\/index.php\/2022\/01\/identificados-os-primeiros-pacientes-com-nova-doenca-rara-causada-por-erros-na-divisao-celular\/saude\/16\/05\/\" \/>\n<meta property=\"og:site_name\" content=\"Algarve 7\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/algarve7\" \/>\n<meta property=\"article:author\" content=\"https:\/\/www.facebook.com\/algarve7\" \/>\n<meta property=\"article:published_time\" content=\"2022-01-20T16:05:27+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-01-20T16:05:32+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/algarve7.pt\/wp-content\/uploads\/2022\/01\/Defective-chromosome-Sara-Carvalhal-2022.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1600\" \/>\n\t<meta property=\"og:image:height\" content=\"1000\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Algarve 7\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@Algarvesete\" \/>\n<meta name=\"twitter:site\" content=\"@Algarvesete\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"Algarve 7\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tempo estimado de leitura\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/algarve7.pt\\\/index.php\\\/2022\\\/01\\\/identificados-os-primeiros-pacientes-com-nova-doenca-rara-causada-por-erros-na-divisao-celular\\\/saude\\\/16\\\/05\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/algarve7.pt\\\/index.php\\\/2022\\\/01\\\/identificados-os-primeiros-pacientes-com-nova-doenca-rara-causada-por-erros-na-divisao-celular\\\/saude\\\/16\\\/05\\\/\"},\"author\":{\"name\":\"Algarve 7\",\"@id\":\"https:\\\/\\\/algarve7.pt\\\/#\\\/schema\\\/person\\\/23fa70681308e7b319a3204bcea45e0c\"},\"headline\":\"Identificados os primeiros pacientes com nova doen\u00e7a rara causada por erros na divis\u00e3o celular\",\"datePublished\":\"2022-01-20T16:05:27+00:00\",\"dateModified\":\"2022-01-20T16:05:32+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/algarve7.pt\\\/index.php\\\/2022\\\/01\\\/identificados-os-primeiros-pacientes-com-nova-doenca-rara-causada-por-erros-na-divisao-celular\\\/saude\\\/16\\\/05\\\/\"},\"wordCount\":982,\"publisher\":{\"@id\":\"https:\\\/\\\/algarve7.pt\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/algarve7.pt\\\/index.php\\\/2022\\\/01\\\/identificados-os-primeiros-pacientes-com-nova-doenca-rara-causada-por-erros-na-divisao-celular\\\/saude\\\/16\\\/05\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/algarve7.pt\\\/wp-content\\\/uploads\\\/2022\\\/01\\\/Defective-chromosome-Sara-Carvalhal-2022.png\",\"keywords\":[\"ABC\",\"Sa\u00fade\"],\"articleSection\":[\"Sa\u00fade\"],\"inLanguage\":\"pt-PT\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/algarve7.pt\\\/index.php\\\/2022\\\/01\\\/identificados-os-primeiros-pacientes-com-nova-doenca-rara-causada-por-erros-na-divisao-celular\\\/saude\\\/16\\\/05\\\/\",\"url\":\"https:\\\/\\\/algarve7.pt\\\/index.php\\\/2022\\\/01\\\/identificados-os-primeiros-pacientes-com-nova-doenca-rara-causada-por-erros-na-divisao-celular\\\/saude\\\/16\\\/05\\\/\",\"name\":\"Identificados os primeiros pacientes com nova doen\u00e7a rara causada por erros na divis\u00e3o celular - Algarve 7\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/algarve7.pt\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/algarve7.pt\\\/index.php\\\/2022\\\/01\\\/identificados-os-primeiros-pacientes-com-nova-doenca-rara-causada-por-erros-na-divisao-celular\\\/saude\\\/16\\\/05\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/algarve7.pt\\\/index.php\\\/2022\\\/01\\\/identificados-os-primeiros-pacientes-com-nova-doenca-rara-causada-por-erros-na-divisao-celular\\\/saude\\\/16\\\/05\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/algarve7.pt\\\/wp-content\\\/uploads\\\/2022\\\/01\\\/Defective-chromosome-Sara-Carvalhal-2022.png\",\"datePublished\":\"2022-01-20T16:05:27+00:00\",\"dateModified\":\"2022-01-20T16:05:32+00:00\",\"description\":\"Identificados os primeiros pacientes com nova doen\u00e7a rara causada por erros na divis\u00e3o celular Sa\u00fade\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/algarve7.pt\\\/index.php\\\/2022\\\/01\\\/identificados-os-primeiros-pacientes-com-nova-doenca-rara-causada-por-erros-na-divisao-celular\\\/saude\\\/16\\\/05\\\/#breadcrumb\"},\"inLanguage\":\"pt-PT\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/algarve7.pt\\\/index.php\\\/2022\\\/01\\\/identificados-os-primeiros-pacientes-com-nova-doenca-rara-causada-por-erros-na-divisao-celular\\\/saude\\\/16\\\/05\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"pt-PT\",\"@id\":\"https:\\\/\\\/algarve7.pt\\\/index.php\\\/2022\\\/01\\\/identificados-os-primeiros-pacientes-com-nova-doenca-rara-causada-por-erros-na-divisao-celular\\\/saude\\\/16\\\/05\\\/#primaryimage\",\"url\":\"https:\\\/\\\/algarve7.pt\\\/wp-content\\\/uploads\\\/2022\\\/01\\\/Defective-chromosome-Sara-Carvalhal-2022.png\",\"contentUrl\":\"https:\\\/\\\/algarve7.pt\\\/wp-content\\\/uploads\\\/2022\\\/01\\\/Defective-chromosome-Sara-Carvalhal-2022.png\",\"width\":1600,\"height\":1000},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/algarve7.pt\\\/index.php\\\/2022\\\/01\\\/identificados-os-primeiros-pacientes-com-nova-doenca-rara-causada-por-erros-na-divisao-celular\\\/saude\\\/16\\\/05\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"In\u00edcio\",\"item\":\"https:\\\/\\\/algarve7.pt\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Identificados os primeiros pacientes com nova doen\u00e7a rara causada por erros na divis\u00e3o celular\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/algarve7.pt\\\/#website\",\"url\":\"https:\\\/\\\/algarve7.pt\\\/\",\"name\":\"Algarve 7\",\"description\":\"Informa\u00e7\u00e3o sobre o Algarve\",\"publisher\":{\"@id\":\"https:\\\/\\\/algarve7.pt\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/algarve7.pt\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"pt-PT\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/algarve7.pt\\\/#organization\",\"name\":\"Algarve 7\",\"url\":\"https:\\\/\\\/algarve7.pt\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"pt-PT\",\"@id\":\"https:\\\/\\\/algarve7.pt\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/algarve7.pt\\\/wp-content\\\/uploads\\\/2020\\\/10\\\/Logo-8.jpg\",\"contentUrl\":\"https:\\\/\\\/algarve7.pt\\\/wp-content\\\/uploads\\\/2020\\\/10\\\/Logo-8.jpg\",\"width\":1680,\"height\":1186,\"caption\":\"Algarve 7\"},\"image\":{\"@id\":\"https:\\\/\\\/algarve7.pt\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/algarve7\",\"https:\\\/\\\/x.com\\\/Algarvesete\",\"https:\\\/\\\/www.instagram.com\\\/jornalalgarve7\\\/\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/algarve7\",\"https:\\\/\\\/www.pinterest.pt\\\/geral0939\\\/_created\\\/\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/algarve7.pt\\\/#\\\/schema\\\/person\\\/23fa70681308e7b319a3204bcea45e0c\",\"name\":\"Algarve 7\",\"sameAs\":[\"https:\\\/\\\/algarve7.pt\",\"https:\\\/\\\/www.facebook.com\\\/algarve7\"],\"url\":\"https:\\\/\\\/algarve7.pt\\\/index.php\\\/author\\\/geralalgarve7-pt\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Identificados os primeiros pacientes com nova doen\u00e7a rara causada por erros na divis\u00e3o celular - Algarve 7","description":"Identificados os primeiros pacientes com nova doen\u00e7a rara causada por erros na divis\u00e3o celular Sa\u00fade","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/algarve7.pt\/index.php\/2022\/01\/identificados-os-primeiros-pacientes-com-nova-doenca-rara-causada-por-erros-na-divisao-celular\/saude\/16\/05\/","og_locale":"pt_PT","og_type":"article","og_title":"Identificados os primeiros pacientes com nova doen\u00e7a rara causada por erros na divis\u00e3o celular - Algarve 7","og_description":"Identificados os primeiros pacientes com nova doen\u00e7a rara causada por erros na divis\u00e3o celular Sa\u00fade","og_url":"https:\/\/algarve7.pt\/index.php\/2022\/01\/identificados-os-primeiros-pacientes-com-nova-doenca-rara-causada-por-erros-na-divisao-celular\/saude\/16\/05\/","og_site_name":"Algarve 7","article_publisher":"https:\/\/www.facebook.com\/algarve7","article_author":"https:\/\/www.facebook.com\/algarve7","article_published_time":"2022-01-20T16:05:27+00:00","article_modified_time":"2022-01-20T16:05:32+00:00","og_image":[{"width":1600,"height":1000,"url":"https:\/\/algarve7.pt\/wp-content\/uploads\/2022\/01\/Defective-chromosome-Sara-Carvalhal-2022.png","type":"image\/png"}],"author":"Algarve 7","twitter_card":"summary_large_image","twitter_creator":"@Algarvesete","twitter_site":"@Algarvesete","twitter_misc":{"Escrito por":"Algarve 7","Tempo estimado de leitura":"5 minutos"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/algarve7.pt\/index.php\/2022\/01\/identificados-os-primeiros-pacientes-com-nova-doenca-rara-causada-por-erros-na-divisao-celular\/saude\/16\/05\/#article","isPartOf":{"@id":"https:\/\/algarve7.pt\/index.php\/2022\/01\/identificados-os-primeiros-pacientes-com-nova-doenca-rara-causada-por-erros-na-divisao-celular\/saude\/16\/05\/"},"author":{"name":"Algarve 7","@id":"https:\/\/algarve7.pt\/#\/schema\/person\/23fa70681308e7b319a3204bcea45e0c"},"headline":"Identificados os primeiros pacientes com nova doen\u00e7a rara causada por erros na divis\u00e3o celular","datePublished":"2022-01-20T16:05:27+00:00","dateModified":"2022-01-20T16:05:32+00:00","mainEntityOfPage":{"@id":"https:\/\/algarve7.pt\/index.php\/2022\/01\/identificados-os-primeiros-pacientes-com-nova-doenca-rara-causada-por-erros-na-divisao-celular\/saude\/16\/05\/"},"wordCount":982,"publisher":{"@id":"https:\/\/algarve7.pt\/#organization"},"image":{"@id":"https:\/\/algarve7.pt\/index.php\/2022\/01\/identificados-os-primeiros-pacientes-com-nova-doenca-rara-causada-por-erros-na-divisao-celular\/saude\/16\/05\/#primaryimage"},"thumbnailUrl":"https:\/\/algarve7.pt\/wp-content\/uploads\/2022\/01\/Defective-chromosome-Sara-Carvalhal-2022.png","keywords":["ABC","Sa\u00fade"],"articleSection":["Sa\u00fade"],"inLanguage":"pt-PT"},{"@type":"WebPage","@id":"https:\/\/algarve7.pt\/index.php\/2022\/01\/identificados-os-primeiros-pacientes-com-nova-doenca-rara-causada-por-erros-na-divisao-celular\/saude\/16\/05\/","url":"https:\/\/algarve7.pt\/index.php\/2022\/01\/identificados-os-primeiros-pacientes-com-nova-doenca-rara-causada-por-erros-na-divisao-celular\/saude\/16\/05\/","name":"Identificados os primeiros pacientes com nova doen\u00e7a rara causada por erros na divis\u00e3o celular - Algarve 7","isPartOf":{"@id":"https:\/\/algarve7.pt\/#website"},"primaryImageOfPage":{"@id":"https:\/\/algarve7.pt\/index.php\/2022\/01\/identificados-os-primeiros-pacientes-com-nova-doenca-rara-causada-por-erros-na-divisao-celular\/saude\/16\/05\/#primaryimage"},"image":{"@id":"https:\/\/algarve7.pt\/index.php\/2022\/01\/identificados-os-primeiros-pacientes-com-nova-doenca-rara-causada-por-erros-na-divisao-celular\/saude\/16\/05\/#primaryimage"},"thumbnailUrl":"https:\/\/algarve7.pt\/wp-content\/uploads\/2022\/01\/Defective-chromosome-Sara-Carvalhal-2022.png","datePublished":"2022-01-20T16:05:27+00:00","dateModified":"2022-01-20T16:05:32+00:00","description":"Identificados os primeiros pacientes com nova doen\u00e7a rara causada por erros na divis\u00e3o celular Sa\u00fade","breadcrumb":{"@id":"https:\/\/algarve7.pt\/index.php\/2022\/01\/identificados-os-primeiros-pacientes-com-nova-doenca-rara-causada-por-erros-na-divisao-celular\/saude\/16\/05\/#breadcrumb"},"inLanguage":"pt-PT","potentialAction":[{"@type":"ReadAction","target":["https:\/\/algarve7.pt\/index.php\/2022\/01\/identificados-os-primeiros-pacientes-com-nova-doenca-rara-causada-por-erros-na-divisao-celular\/saude\/16\/05\/"]}]},{"@type":"ImageObject","inLanguage":"pt-PT","@id":"https:\/\/algarve7.pt\/index.php\/2022\/01\/identificados-os-primeiros-pacientes-com-nova-doenca-rara-causada-por-erros-na-divisao-celular\/saude\/16\/05\/#primaryimage","url":"https:\/\/algarve7.pt\/wp-content\/uploads\/2022\/01\/Defective-chromosome-Sara-Carvalhal-2022.png","contentUrl":"https:\/\/algarve7.pt\/wp-content\/uploads\/2022\/01\/Defective-chromosome-Sara-Carvalhal-2022.png","width":1600,"height":1000},{"@type":"BreadcrumbList","@id":"https:\/\/algarve7.pt\/index.php\/2022\/01\/identificados-os-primeiros-pacientes-com-nova-doenca-rara-causada-por-erros-na-divisao-celular\/saude\/16\/05\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"In\u00edcio","item":"https:\/\/algarve7.pt\/"},{"@type":"ListItem","position":2,"name":"Identificados os primeiros pacientes com nova doen\u00e7a rara causada por erros na divis\u00e3o celular"}]},{"@type":"WebSite","@id":"https:\/\/algarve7.pt\/#website","url":"https:\/\/algarve7.pt\/","name":"Algarve 7","description":"Informa\u00e7\u00e3o sobre o Algarve","publisher":{"@id":"https:\/\/algarve7.pt\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/algarve7.pt\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"pt-PT"},{"@type":"Organization","@id":"https:\/\/algarve7.pt\/#organization","name":"Algarve 7","url":"https:\/\/algarve7.pt\/","logo":{"@type":"ImageObject","inLanguage":"pt-PT","@id":"https:\/\/algarve7.pt\/#\/schema\/logo\/image\/","url":"https:\/\/algarve7.pt\/wp-content\/uploads\/2020\/10\/Logo-8.jpg","contentUrl":"https:\/\/algarve7.pt\/wp-content\/uploads\/2020\/10\/Logo-8.jpg","width":1680,"height":1186,"caption":"Algarve 7"},"image":{"@id":"https:\/\/algarve7.pt\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/algarve7","https:\/\/x.com\/Algarvesete","https:\/\/www.instagram.com\/jornalalgarve7\/","https:\/\/www.linkedin.com\/company\/algarve7","https:\/\/www.pinterest.pt\/geral0939\/_created\/"]},{"@type":"Person","@id":"https:\/\/algarve7.pt\/#\/schema\/person\/23fa70681308e7b319a3204bcea45e0c","name":"Algarve 7","sameAs":["https:\/\/algarve7.pt","https:\/\/www.facebook.com\/algarve7"],"url":"https:\/\/algarve7.pt\/index.php\/author\/geralalgarve7-pt\/"}]}},"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/algarve7.pt\/wp-content\/uploads\/2022\/01\/Defective-chromosome-Sara-Carvalhal-2022.png","jetpack_shortlink":"https:\/\/wp.me\/pcezmW-3Qj","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/algarve7.pt\/index.php\/wp-json\/wp\/v2\/posts\/14775","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/algarve7.pt\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/algarve7.pt\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/algarve7.pt\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/algarve7.pt\/index.php\/wp-json\/wp\/v2\/comments?post=14775"}],"version-history":[{"count":0,"href":"https:\/\/algarve7.pt\/index.php\/wp-json\/wp\/v2\/posts\/14775\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/algarve7.pt\/index.php\/wp-json\/wp\/v2\/media\/14776"}],"wp:attachment":[{"href":"https:\/\/algarve7.pt\/index.php\/wp-json\/wp\/v2\/media?parent=14775"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/algarve7.pt\/index.php\/wp-json\/wp\/v2\/categories?post=14775"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/algarve7.pt\/index.php\/wp-json\/wp\/v2\/tags?post=14775"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}